I just read a book that used an unusual font, a sans-serif one like this in an overly large size.
It made the book very hard to read. I wouldn’t have thought it would make that big a deal, but it did. It didn’t help that it wasn’t a particularly good book to begin with, but it’s interesting to feel the effects of font selection on my reading attitude.
Online, fonts don’t matter all that much to me, but in print, they matter. A lot.